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. 2019 Nov 6;8(11):1887. doi: 10.3390/jcm8111887

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A). Timeline of the intracranial optogenetic self-stimulation (ICSS) experiments. (B). Schematic representation of the ICSS procedure and the cue-induced reinstatement phase. (C). Active and inactive lever presses during the cue-induced reinstatement period for cKO and control mice. (D,E). Average of inactive (D) and active (E) during the cue-induced reinstatement phase cKO and Ctrl mice. Data are presented as mean ± SEM. *** p < 0.001 vs. ctrl. Ctrl n = 3, cKO n = 3. Original data, Bimpisidis and Wallén-Mackenzie, pilot study, 2019.