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. 2019 Nov 6;8(11):1887. doi: 10.3390/jcm8111887

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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VGLUT2 targeting in mature DA neurons results in an elevated baseline AMPA/NMDA ratio. (A) AMPA/NMDA ratio and raw traces of cells from Vglut2^{f/fDAT-CreERT} cKO and ctrl mice treated with saline or cocaine for NMDA current (blue); AMPA current (light gray). (B) Rectification index (RI) and raw traces recorded cells from Vglut2^{f/fDAT-CreERT} cKO and ctrl mice treated with saline or cocaine. eKO-DRD1 and eCtrl-DRD1 mice treated with saline or cocaine at −70 mV (blue), 0 mV (light gray) and +40 mV (dark gray). Two-way ANOVA Sidak post hoc (ANOVA ###p < 0.001; post hoc between genotype *p < 0.05 and post hoc between treatment of same genotype: *p < 0.05, **p < 0.01, ***p < 0.001; RI saline: saline Vglut2^{f/fDAT-CreERT} Ctrl, n = 6, Vglut2^{f/fDAT-CreERT} cKO, n = 6; cocaine: Vglut2^{f/fDAT-CreERT} Ctrl, n = 12; Vglut2^{f/fDAT-CreERT} cKO, n = 7; AMPA/NMDA ratio saline:: Vglut2^{f/fDAT-CreERT} Ctrl, n = 9, Vglut2^{f/fDAT-CreERT} cKO, n = 9; cocaine: Vglut2^{f/fDAT-CreERT} Ctrl, n = 13, Vglut2^{f/fDAT-CreERT} cKO, n = 7). Whole-cell patch clamp experiments performed on slices 10 days after last saline or cocaine injection. Reprinted from Papathanou et al., 2018 [24].