Table 4.
Statistical analysis discriminating accuracy of malignant and benign thyroid nodule diagnosis when assigning the EU-TIRADS category cut-off (PPV—positive predictive value, NPV—negative predictive value, OR—odds ratio). Not applicable (NA) is presented to avoid dividing by zero.
| EU-TIRADS Score | Positive | Negative | Value | CI (95%) | ||
|---|---|---|---|---|---|---|
| ≥3 | Malignant | 229 | 0 | Sensitivity (%) | 100.0 | 98.4–100.0 |
| Benign | 459 | 154 | Specificity (%) | 25.1 | 21.7–28.8 | |
| Accuracy (%) | 45.5 | 42.1–48.9 | ||||
| PPV (%) | 33.3 | 29.8–36.9 | ||||
| NPV (%) | 100 | 97.6–100.0 | ||||
| OR | NA | NA | ||||
| ≥4 | Malignant | 226 | 3 | Sensitivity (%) | 98.7 | 96.2–99.7 |
| Benign | 369 | 244 | Specificity (%) | 39.8 | 35.9–43.8 | |
| Accuracy (%) | 55.8 | 52.4–59.2 | ||||
| PPV (%) | 38 | 34.1–42.0 | ||||
| NPV (%) | 98.8 | 96.5–99.7 | ||||
| OR | 49.8 | 15.8–157.4 | ||||
| 5 | Malignant | 214 | 15 | Sensitivity (%) | 93.4 | 89.4–96.3 |
| Benign | 278 | 335 | Specificity (%) | 54.6 | 50.6–58.6 | |
| Accuracy (%) | 65.2 | 61.9–68.4 | ||||
| PPV (%) | 43.5 | 39.1–48.0 | ||||
| NPV (%) | 95.7 | 93–97.6 | ||||
| OR | 17.2 | 9.95–29.71 | ||||