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. 2019 Oct 24;8(11):1310. doi: 10.3390/cells8111310

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Lentiviral genome organization. Lentiviral genomes share significant similarities with respect to the location of the structural gag, pol, and env genes. However, they differ in number and type of accessory proteins. All but EIAV encode a vif gene, and all primate lentiviruses (i.e., human and simian immunodeficiency viruses) encode vpr and nef genes, whereas vpu and vpx genes are limited to HIV-1 and HIV-2 and related viruses, respectively. HIV = Human Immunodeficiency Virus, SIV = Simian Immunodeficiency Virus, EIAV = Equine Infectious Anemia Virus, CAEV = Caprine Arthritis Encephalitis Virus, JDV = Jembrana Disease Virus, BIV = Bovine Immunodeficiency Virus.