Table 1.
Patient characteristics and medication use by hyponatremia category.
| All Patients (N = 184) n (%) |
Normonatremia (N = 112) n (%) |
Hyponatremia (N = 72) n (%) |
|
|---|---|---|---|
| Median age (IQR) 1, years | 38 (29–56) | 34 (29–52) | 46 (32–64) |
| Male sex (%) | 89 (48.4) | 51 (45.5) | 38 (52.8) |
| Diabetes (%) | 18 (9.8) | 8 (7.1) | 10 (13.9) |
| Heart failure (%) | 3 (1.6) | 2 (1.8) | 1 (1.4) |
| eGFR 2 <60/mL/min/1.73m2 | 8 (4.4) | 3 (2.7) | 5 (6.9) |
| Encephalitis syndrome (%) | 46 (25.0) | 17 (15.2) | 29 (40.3) |
| Acute kidney injury (%) | 12 (6.5) | 4 (3.6) | 8 (11.1) |
| Acyclovir 3 (%) | 79 (42.9) | 41 (36.6) | 38 (52.8) |
| Diuretics (%) | 17 (9.2) | 9 (8.0) | 8 (11.1) |
| Angiotensin system inhibitor (%) | 18 (9.8) | 10 (8.9) | 8 (11.1) |
| Antidepressants (%) | 22 (12.0) | 11 (9.8) | 11 (15.3) |
| Antiepileptics (%) | 10 (5.4) | 4 (3.6) | 6 (8.3) |
| Antipsychotics (%) | 2 (1.1) | 2 (1.8) | 0 (0) |
1 interquartile range, 2 estimated glomerular filtration rate, 3 41% (32/79) had hyponatremia prior to acyclovir.