Table 4.
Management of VOCs during the DOVE study.
| Parameter Assessed (n (%)) | Geographic Regions a | ||||
|---|---|---|---|---|---|
| SSA (N = 148) | Americas (N = 57) | North Africa/Middle East (N = 110) | EuropeZ (N = 26) | Total (N = 341) | |
| Total Number of VOCs | 296 | 200 | 226 | 96 | 818 |
| Location of Medical Intervention b | |||||
| VOCs managed by outpatient hospital visit | 201 (67.9) | 10 (5.0) | 44 (19.5) | 6 (6.3) | 261 (31.9) |
| VOCs managed by inpatient hospital visit | 71 (24.0) | 89 (44.5) | 75 (33.2) | 53 (55.2) | 288 (35.2) |
| VOCs managed by home support visits c | 10 (3.4) | 18 (9.5) | 1 (0.5) | 16 (18.4) | 45 (5.7) |
| VOCs managed by telephone consultation c | 5 (1.7) | 52 (27.4) | 46 (21.1) | 5 (5.7) | 108 (13.8) |
| VOCs managed by emergency room visit | 9 (3.0) | 24 (12.0) | 58 (25.7) | 16 (16.7) | 107 (13.1) |
| Types of Medical Intervention | |||||
| VOCs requiring analgesics | 295 (99.7) | 199 (99.5) | 224 (99.1) | 96 (100.0) | 814 (99.5) |
| VOCs requiring IV fluids | 136 (45.9) | 113 (56.5) | 150 (66.4) | 46 (47.9) | 445 (54.4) |
| VOCs requiring transfusion | 19 (6.4) | 20 (10.0) | 42 (18.6) | 18 (18.8) | 99 (12.1) |
Abbreviations: ACS = acute chest syndrome; IV = intravenous; n = number of events in the specified category; N = number of randomized subjects; SSA = Sub-Saharan Africa; VOCs = vaso-occlusive crises. (a) The SSA subgroup includes Ghana and Kenya; the Americas subgroup includes Brazil, the United States, and Canada; the North Africa/Middle East subgroup includes Saudi Arabia, Oman, Egypt, Lebanon, and Turkey; the Europe subgroup includes Belgium, Italy, and the United Kingdom (Heeney et al.) [9]. (b) Professional health care office/clinic visits and urgent care visits are not included in the table since all regions utilized them for ≤2% of VOCs. (c) Home support visits and telephone consultations were available for episodes of painful crisis only, not ACS.