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In vitro chemosensitivity of normal and tumor CRCs. Differential toxicity of SAHA and cisplatin was established in the matched normal and tumor CR cells via ATP bioluminescence. Malignant cells showed more sensitivity to both compounds by displaying a median curative dose of 1.09 µM for Vorinostat (SAHA) and 10.47 µM for cisplatin compared to 5.83 µM and 39.91 µM respectively for the normal line (p values: 0.011 and 0.014).
