Table 1.

Characteristics of the included systematic reviews.

Type of Anticoagulant	Author	Population	Number of Trials	Number of Patients	AMSTAR
Antithrombin	Wiedermann, 2006 [13]	Sepsis-induced DIC	3	364	10
	Afshari, 2008 [28]	Critically ill	20	3458	11
	Allingstrup, 2016 [10]	Critically ill	30	3933	11
	Wiedermann, 2018 [11]	Sepsis-induced DIC	12	766	7
Thrombomodulin	Yamakawa, 2015 [14]	Sepsis-induced DIC	3	838	10
	Zhang, 2016 [15]	Sepsis-induced DIC	2	821	9
	Yamakawa, 2019 [9]	Sepsis with coagulopathy	5	1762	10
Heparin/	Wang, 2014 [16]	Sepsis	6	604	9
	Zarychanski, 2015 [17]	Sepsis	6	2477	9
Low-molecular-weight heparin	Fan, 2016 [18]	Sepsis	11	594	8
Activated protein C	Kylat, 2006 [19]	Neonate with sepsis	0	NA	11
	Costa, 2007 [20]	Severe sepsis	2	4330	7
	Martí-Carvajal, 2007 [21]	Severe sepsis	4	4911	11
	Martí-Carvajal, 2008 [22]	Severe sepsis	4	4911	11
	Martí-Carvajal, 2011 [24]	Severe sepsis	5	5101	11
	Kylat, 2012 [23]	Neonates with sepsis	0	NA	11
	Martí-Carvajal, 2012 [25]	Severe sepsis	5	5101	11
	Martí-Carvajal, 2012 [26]	Adult and pediatric sepsis	6	6781	11
All anticoagulants	Umemura, 2016 [27]	Sepsis, Sepsis with coagulopathy, Sepsis-induced DIC	24	14767	10

DIC = disseminated intravascular coagulation; NA = not available.