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Pivotal study of 5-aminolevulinic acid (ALA)-mediated sonodynamic effect on a rat C6 glioma model in vivo. A significant reduction of the tumor mass after sonodynamic therapy is shown (C). The other photos show the control groups, namely: untreated (A), 5-ALA only (B), and ultrasound only (D). This figure has been reproduced from the literature [50], with permission from the publisher.
