Table 1.

Phenotypic Surface Markers of Canine NK Cells based on Current Evidence.

Known Canine NK Cell Activating Receptors
Receptor	Gene	Verified by	Additional info	Homology
CD5dim	CD5	Flow cytometry	15% of PBMCs	Human, mouse
NKp46	NCR1	Flow cytometry	2.5% of PBMCs	Human, mouse
CD16	FCGR3A	DNA Sequencing	Absent/not annotated on CanFam3.1 assembly	Human, mouse
NKG2D	KLRK1	DNA Sequencing	Annotated on CanFam3.1 assembly	Human, mouse
CD3	CD3E	Flow cytometry	Typically a T-cell marker, persists in candidate populations of canine NK cells	Human, mouse
Known Canine NK Cell MHC-I Inhibitory Receptors
Receptor	Gene	Verified by	Additional info	Homology
Ly49	Ly49	DNA sequencing, Southern blot	Cysteine-to-tyrosine mutation present, function unknown	Mouse
CD94	KLRD1	Flow cytometry	7% of PBMCs. Function unknown, lack of NKG2A to form heterodimer	Human, mouse
KIR	Absent	DNA sequencing	LRC appears to be truncated prior to KIR gene locations	Human