Table 1. . Pattern of change of serum and cerebrospinal fluid markers in CNS leukemia.
| Biomarker | Pattern of change in CNSL compared with non CNSL | p-value |
|---|---|---|
| VCAM-1 CSF | Lower | 0.227 |
| VCAM-1 serum | Lower | 0.802 |
| MMP-9 CSF | Higher | 0.909 |
| MMP-9 serum | Higher | 0.096 |
| MCP-1/CCL2 CSF | Lower | 0.632 |
| MCP-1/CCL2 serum | Lower | 0.065 |
| IFN-gamma CSF | Lower | 0.327 |
| IFN-gamma serum | Higher | 0.425 |
| IP-10/CR CSF | Lower | 0.412 |
| IP-10/CR serum | Lower | 0.151 |
CNSL: Central nervous system leukemia; CSF: Cerebrospinal fluid; IP-10: Inducible protein 10; MCP-1: Monocyte chemotactic protein 1; MMP-9: Matrix metalloprotienase 9; VCAM-1: Vascular cell adhesion molecule-1.