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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Radiother Oncol. 2019 Sep 17;141:137–143. doi: 10.1016/j.radonc.2019.08.020

Table 4.

Cox Proportional Hazards Models

Overall Survival Biochemical Failure Distant Metastases
Covariate Comparison HR (95% CI) p-value HR (95% CI) p-value HR (95% CI) p-value
Gleason (grouped) GP5 (RL) vs No GP5 0.73
(0.63, 0.85)		 <0.0001 0.78
(0.66, 0.92)		 0.0038 0.38
(0.30, 0.48)		 <0.0001
Age Continuous 1.05
(1.04, 1.06)		 <0.0001 0.97
(0.96, 0.98)		 <0.0001 0.96
(0.94, 0.97)		 <0.0001
PSA < 30 (RL) vs ≥ 30 1.03
(0.91, 1.16)		 0.6673 1.49
(1.30, 1.71)		 <0.0001 1.33
(1.06, 1.66)		 0.0148
Intercurrent disease No (RL) vs Yes 1.07
(1.01, 1.14)		 0.0326 0.99
(0.89, 1.09)		 0.7958 0.85
(0.67, 1.09)		 0.1947
T-Stage T1/T2 (RL) vs T3/T4 1.15
(1.02, 1.29)		 0.0181 1.21
(1.06, 1.38)		 0.0056 1.70
(1.35, 2.13)		 <0.0001
Study 9202 (RL) vs 9902 0.78
(0.64, 0.94)		 0.0100 0.95
(0.80, 1.12)		 0.5369 0.48
(0.34, 0.66)		 <0.0001

GP = Gleason pattern, RL = reference level, HR = hazard ratio, CI = confidence interval Patients with unknown intercurrent disease were excluded from the model.