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The plant hormone auxin promotes the interaction between TIR1 and IAA7. TIR1 (green) is a ubiquitin ligase substrate adapter to which TIR1 (blue) is recruited. Auxin (orange) binds to TIR1 at the interface with IAA7 and increases the affinity for the interaction of E3 ligase and substrate to promote substrate ubiquitination and degradation.
