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. 2019 Nov 12;10(12):1592–1602. doi: 10.1021/acsmedchemlett.9b00425

Figure 5.

Figure 5

CRBN interacts with a similar feature on the substrate proteins GSPT1, CK1α, and Ikaros. CRBN (green) bound to GSPT1 (a, blue, PDB ID: 5HXB), CK1α (b, blue, PDB ID: 5FQD), or Ikaros (c, blue, PDB ID: 6H0F) interacts with a hairpin on the substrate protein. Ligands are represented as sticks (maroon) with CC-885 present in panel a, lenalidomide present in panel b, and pomalidomide present in panel c. The same pattern of three direct hydrogen bonds from residues N351, H357 and W400 is present between CRBN and GSPT1, CK1α, or Ikaros.