Iberdomide
makes more extensive interactions with the cereblon
surface than lenalidomide. Crystal structures of cereblon (green)
bound to either lenalidomide (a, red, PDB ID: 4TZ4) or iberdomide (b,
red, PDB ID: 5V3O) demonstrate the increased surface interactions of iberdomide compared
to lenalidomide, contributing to the increased potency of iberdomide.