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. 2019 Nov 12;10(12):1592–1602. doi: 10.1021/acsmedchemlett.9b00425

Figure 6.

Figure 6

Iberdomide makes more extensive interactions with the cereblon surface than lenalidomide. Crystal structures of cereblon (green) bound to either lenalidomide (a, red, PDB ID: 4TZ4) or iberdomide (b, red, PDB ID: 5V3O) demonstrate the increased surface interactions of iberdomide compared to lenalidomide, contributing to the increased potency of iberdomide.