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. 2019 Dec 4;10(12):1655–1660. doi: 10.1021/acsmedchemlett.9b00452

Figure 1.

Figure 1

Overlay of X-ray crystal structures of Dot1L with SAM (pdb 1nw3) and 1 (undisclosed structure). Cartoon representation of Dot1L (gray) with the flexible loop 126–140 shown in light blue for SAM and red for 1; stick models of ligands 1 (red) and SAM (blue). The residues Phe129 and Pro130 that form the roof of the induced pocket are shown as sticks.