Table 3.

Longitudinal mixed effects model results for effect of group (TSC+ASD and TSC-ASD) and group interactions with age on fractional anisotropy of white matter regions. Likelihood ratio tests were used to attain p values. Italicized p values indicate p < 0.05

	White matter region of interest	Group			Group × baseline age			Group × longitudinal age
		Est	χ2	p	Est	χ2	p	Est	χ2	p
Left	Arcuate: waypoint to Broca’s	− 0.018	6.07	0.01	− 0.017	1.40	0.24	0.006	1.01	0.32
	Arcuate: Geschwind’s territory	− 0.016	5.62	0.02	0.004	0.08	0.78	0.004	0.96	0.33
	Arcuate: Wernicke’s area	− 0.023	12.41	<0.001	− 0.006	0.24	0.62	0.005	1.10	0.30
	Anterior limb internal capsule	− 0.015	4.42	0.04	0.01	0.47	0.49	0.002	0.21	0.65
	Cingulum	− 0.011	4.48	0.03	− 0.009	0.66	0.42	0.002	0.27	0.61
	Inferior extreme capsule	− 0.006	1.18	0.28	− 0.002	0.02	0.88	0.001	0.03	0.86
	Posterior limb internal capsule	− 0.009	1.46	0.23	− 0.005	0.14	0.71	− 0.01	0.53	0.47
	Sagittal stratum	− 0.003	0.10	0.75	0.023	1.45	0.23	0.004	0.22	0.64
Midline	Corpus callosum	− 0.024	11.66	<0.001	− 0.008	0.39	0.54	0.007	1.63	0.20
Right	Arcuate: waypoint to Broca’s	− 0.024	11.42	<0.001	0.006	0.19	0.66	0.006	1.56	0.21
	Arcuate: Geschwind’s territory	− 0.004	0.42	0.52	0.013	1.12	0.29	− 0.000	0.02	0.90
	Arcuate: Wernicke’s area	− 0.013	3.97	0.05	0.004	0.08	0.78	0.002	0.26	0.61
	Anterior limb internal capsule	− 0.020	9.22	0.002	0.001	0.01	0.94	0.003	0.34	0.56
	Cingulum	− 0.010	3.94	0.05	0.000	0.00	0.99	0.007	3.05	0.08
	Inferior extreme capsule	− 0.002	0.16	0.69	0.010	0.92	0.34	− 0.002	0.49	0.48
	Posterior limb internal capsule	− 0.003	0.31	0.58	0.003	0.06	0.81	− 0.002	0.13	0.72
	Sagittal stratum	− 0.022	6.55	0.01	0.023	1.78	0.18	0.035	13.48	<0.001

Italicized p values indicate p < 0.05