Table 2.
AUC, PPV, NPV, sensitivity and specificity for PMN elastae in patients with myositis
| IIMs | DM | PM | |||||||
|---|---|---|---|---|---|---|---|---|---|
| PMN elastase | CK | ENR | PMN elastase | CK | ENR | PMN elastase | CK | ENR | |
|
AUC (95% CI) |
0.90*** (0.83–0.97) |
0.72** (0.61–0.84) |
0.96*** (0.92–1.0) |
0.90*** (0.82–0.98) |
0.70* (0.57–0.83) |
0.96*** (0.91–1.0) |
0.88* (0.65–1.0) |
0.80* (0.56–1.0) |
1.0** (1.0–1.0) |
|
Cut off value (ng/mL) |
1632.4 | 84.8 | 329.0 | 1632.4 | 107.9 | 329.0 | 1632.4 | 107.9 | 329.0 |
| PPV | 1 | 0.89 | 0.98 | 1 | 1 | 0.98 | 1 | 1 | 1 |
| NPV | 0.77 | 0.59 | 0.85 | 0.68 | 0.44 | 0.89 | 0.78 | 0.58 | 1 |
| Sensitivity (%) | 79 | 56 | 88 | 80 | 42.9 | 94 | 80 | 43 | 94 |
| Specificity (%) | 100 | 90 | 97 | 100 | 100 | 96 | 100 | 100 | 96 |
AUC area under the curve, PPV positive predictive value, NPV negative predictive value; 95% CI 95% confidence interval, ENR PMN elastase-to-netrophil ratio
* P < 0.05 for the area under the curve; **P < 0.01 for the area under the curve; ***P < 0.001 for the area under the curve