Table 2.
Association of LAE and AF Status With Baseline Cognitive Domain Scores, Visit 5 (2011–2013), ARIC‐NCS
| Cognitive Domain | Model | Group 1 | Group 2 | Group 3 | Group 4 |
|---|---|---|---|---|---|
| (Normal LA/No AF) (n=2842) | (Normal LA/AF) (n=107) | (LAE/No AF) (n=337) | (LAE/AF) (n=105) | ||
| Memory | 1 | Reference | −0.12 (−0.25 to 0.01) | −0.04 (−0.11 to 0.04) | −0.08 (−0.21 to 0.05) |
| 2 | Reference | −0.13 (−0.26 to 0.01) | −0.03 (−0.10 to 0.05) | −0.07 (−0.20 to 0.07) | |
| 3 | Reference | −0.13 (−0.27 to 0.01) | −0.03 (−0.10 to 0.05) | −0.07 (−0.23 to 0.08) | |
| 4 | Reference | −0.14 (−0.26 to −0.01) | −0.06 (−0.13 to 0.01) | −0.06 (−0.21 to 0.08) | |
| Executive function | 1 | Reference | −0.05 (−0.17 to 0.07) | −0.08 (−0.15 to −0.01)a | −0.28 (−0.40 to −0.15)a |
| 2 | Reference | −0.01 (−0.14 to 0.11) | −0.05 (−0.12 to 0.02) | −0.20 (−0.33 to −0.07)a | |
| 3 | Reference | −0.04 (−0.17 to 0.09) | −0.04 (−0.12 to 0.02) | −0.25 (−0.40 to −0.10)a | |
| 4 | Reference | −0.04 (−0.16 to 0.08) | −0.07 (−0.14 to −0.01) | −0.24 (−0.38 to −0.10)a | |
| Language | 1 | Reference | 0.03 (−0.10 to 0.16) | −0.02 (−0.09 to 0.06) | −0.16 (−0.29 to −0.03)a |
| 2 | Reference | 0.04 (−0.09 to 0.17) | −0.01 (−0.08 to 0.07) | −0.14 (−0.27 to −0.01)a | |
| 3 | Reference | −0.01 (−0.14 to 0.13) | −0.01 (−0.08 to 0.07) | −0.23 (−0.38 to −0.07) | |
| 4 | Reference | −0.01 (−0.14 to 0.12) | −0.03 (−0.10 to 0.04) | −0.22 (−0.36 to −0.07) | |
| Global cognition | 1 | Reference | −0.04 (−0.15 to 0.08) | −0.07 (−0.14 to −0.01)a | −0.23 (−0.35 to −0.12)a |
| 2 | Reference | −0.02 (−0.13 to 0.10) | −0.04 (−0.11 to 0.02) | −0.18 (−0.30 to −0.06)a | |
| 3 | Reference | −0.04 (−0.17 to 0.08)a | −0.04 (−0.11 to 0.02) | −0.24 (−0.38 to −0.10)a | |
| 4 | Reference | −0.05 (−0.16 to 0.06) | −0.07 (−0.13 to −0.01) | −0.23 (−0.36 to −0.11)a |
Model 1, adjusted for age, sex, race/study center, and educational level. Model 2, model 1+apolipoprotein E genotype, smoking, body mass index, systolic and diastolic blood pressure, use of antihypertensive medication, diabetes mellitus, stroke, coronary heart disease or myocardial infarction, and heart failure. Model 3, model 2+anticoagulant use. Model 4, model 3+adjustment for mild cognitive impairment and dementia. Data represented are changes in factor scores. AF indicates atrial fibrillation; ARIC‐NCS, Atherosclerosis Risk in Communities Neurocognitive Study; LA, left atrium; LAE, left atrial enlargement.
Indicates a significant association (95% CI below zero).