Table 3.
Association of LAE and AF Status With Longitudinal Change in Cognitive Domain Scores Between Visit 5 (2011–2013) and Visit 6 (2016–2017), ARIC‐NCS
| Cognitive Domain | Model | Group 1 | Group 2 | Group 3 | Group 4 |
|---|---|---|---|---|---|
| (Normal LA/No AF) (n=2842) | (Normal LA/AF) (n=107) | (LAE/No AF) (n=337) | (LAE/AF) (n=105) | ||
| Memory | 1 | Reference | 0.05 (−0.07 to 0.16) | −0.01 (−0.07 to 0.06) | −0.03 (−0.14 to 0.08) |
| 2 | Reference | 0.06 (−0.06 to 0.17) | −0.01 (−0.08 to 0.05) | −0.01 (−0.13 to 0.10) | |
| 3 | Reference | 0.05 (−0.06 to 0.17) | −0.01 (−0.08 to 0.05) | −0.02 (−0.16 to 0.11) | |
| 4 | Reference | 0.06 (−0.05 to 0.17) | −0.01 (−0.08 to 0.05) | −0.02 (−0.14 to 0.11) | |
| 5 | Reference | 0.02 (−0.08 to 0.12) | −0.02 (−0.08 to 0.04) | −0.03 (−0.15 to 0.08) | |
| 6 | Reference | 0.02 (−0.09 to 0.12) | −0.03 (−0.09 to 0.03) | −0.04 (−0.15 to 0.08) | |
| Executive function | 1 | Reference | −0.13 (−0.23 to −0.04)a | 0.02 (−0.04 to 0.07) | 0.01 (−0.09 to 0.10) |
| 2 | Reference | −0.13 (−0.22 to −0.03)a | 0.01 (−0.04 to 0.07) | −0.01 (−0.10 to 0.10) | |
| 3 | Reference | −0.13 (−0.23 to −0.03)a | 0.01 (−0.04 to 0.07) | −0.01 (−0.12 to 0.12) | |
| 4 | Reference | −0.15 (−0.24 to −0.05)a | 0.01 (−0.04 to 0.07) | 0.01 (−0.10 to 0.11) | |
| 5 | Reference | −0.16 (−0.25 to −0.07)a | 0.01 (−0.05 to 0.06) | −0.05 (−0.16 to 0.05) | |
| 6 | Reference | −0.16 (−0.25 to −0.07)a | 0.01 (−0.06 to 0.05) | −0.06 (−0.16 to 0.04) | |
| Language | 1 | Reference | −0.13 (−0.23 to −0.03)a | −0.02 (−0.08 to 0.04) | −0.04 (−0.14 to 0.06) |
| 2 | Reference | −0.13 (−0.23 to −0.03)a | −0.02 (−0.08 to 0.04) | −0.03 (−0.13 to 0.08) | |
| 3 | Reference | −0.12 (−0.22 to −0.01)a | −0.02 (−0.08 to 0.04) | −0.01 (−0.13 to 0.11) | |
| 4 | Reference | −0.11 (−0.21 to −0.01)a | −0.02 (−0.08 to 0.04) | −0.01 (−0.12 to 0.10) | |
| 5 | Reference | −0.12 (−0.21 to −0.03)a | −0.02 (−0.08 to 0.03) | −0.06 (−0.16 to 0.05) | |
| 6 | Reference | −0.12 (−0.21 to −0.03)a | −0.03 (−0.08 to 0.03) | −0.06 (−0.17 to 0.04) | |
| Global cognition | 1 | Reference | −0.11 (−0.19 to −0.02)a | 0.02 (−0.03 to 0.07) | −0.02 (−0.11 to 0.06) |
| 2 | Reference | −0.10 (−0.18 to −0.02)a | 0.02 (−0.03 to 0.07) | −0.02 (−0.11 to 0.06) | |
| 3 | Reference | −0.11 (−0.20 to −0.02)a | 0.02 (−0.03 to 0.07) | −0.04 (−0.14 to 0.06) | |
| 4 | Reference | −0.13 (−0.21 to −0.05)a | 0.02 (−0.03 to 0.07) | −0.04 (−0.13 to 0.05) | |
| 5 | Reference | −0.13 (−0.21 to −0.06)a | 0.01 (−0.03 to 0.06) | −0.07 (−0.16 to 0.02) | |
| 6 | Reference | −0.14 (−0.22 to −0.06)a | 0.01 (−0.04 to 0.05) | −0.07 (−0.16 to 0.01) |
Model 1, adjusted for age, sex, race/study center, and educational level. Model 2, model 1+apolipoprotein E genotype, smoking, body mass index, systolic and diastolic blood pressure, use of antihypertensive medication, diabetes mellitus, stroke, coronary heart disease or myocardial infarction, and heart failure. Model 3, model 2+anticoagulant use. Model 4, model 3+takes into account inverse probability of attrition weights. Model 5, model 4+adjustment for baseline scores at visit 5. Model 6, model 5+adjustment for mild cognitive impairment and dementia. Data represented are changes in factor scores. AF indicates atrial fibrillation; ARIC‐NCS, Atherosclerosis Risk in Communities Neurocognitive Study; LA, left atrium; LAE, left atrial enlargement.
Indicates a significant association (95% CI below zero).