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Adherence to remote ischemic conditioning (RIC) or sham by dose number and mean total duration of limb ischemia (seconds±SD). Maximum length of cuff inflation is 300 seconds per dose (4× 5 minutes per cycle). Compared with dose 1, there is a significant fall in adherence over time from day 3 (*P=0.001, **P<0.001 repeated measures ANOVA), with no between‐group differences (P=0.64). “n” sham/RIC=dose 1: 29/31; dose 2: 19/21; and doses 3 to 8: 10/10.
