Table 3.
Cox Hazard Model for Univariate and Multivariate Analysis
| HR | 95% CI | P Value | Adjusted HR | 95% CI | P Value | |
|---|---|---|---|---|---|---|
| Primary end point | ||||||
| Adipsin ≥400 ng/mL | 2.5 | 1.8 to 3.5 | <0.001 | 2.0 | 1.2 to 3.2 | 0.007 |
| Men, % | 0.9 | 0.7 to 1.2 | 0.673 | … | … | … |
| Age, y | 1.0 | 1.0 to 1.0 | <0.001 | 1.0 | 1.0 to 1.0 | 0.163 |
| BNP ≥100 pg/mL | 2.1 | 1.6 to 2.6 | <0.001 | 1.8 | 1.2 to 2.8 | 0.006 |
| hsCRP ≥1 mg/L | 1.6 | 1.2 to 2.1 | <0.001 | 1.1 | 0.7 to 1.6 | 0.734 |
| BMI | 1.0 | 0.9 to 1.0 | 0.007 | 1.0 | 0.9 to 1.0 | 0.138 |
| Hypertension, % | 1.3 | 0.9 to 1.7 | 0.114 | … | … | … |
| DM, % | 1.5 | 1.1 to 2.0 | 0.003 | 1.2 | 0.7 to 1.9 | 0.520 |
| Smoke, % | 1.0 | 0.7 to 1.3 | 0.931 | … | … | … |
| Dyslipidemia, % | 1.0 | 0.8 to 1.3 | 0.973 | … | … | … |
| HbA1c, % | 1.2 | 1.1 to 1.3 | 0.005 | 1.3 | 1.1 to 1.5 | 0.009 |
| ACEIs, % | 1.0 | 0.7 to 1.4 | 0.922 | … | … | … |
| ARBs, % | 1.5 | 1.1 to 2.1 | 0.014 | 1.4 | 0.9 to 2.1 | 0.120 |
| CCBs, % | 0.9 | 0.7 to 1.1 | 0.305 | … | … | … |
| Statins, % | 1.2 | 0.9 to 1.5 | 0.267 | … | … | … |
| Aspirin, % | 1.7 | 1.3 to 2.1 | <0.001 | 1.4 | 1.0 to 1.8 | 0.045 |
| eGFR, mL/min per 1.73/m2 | 1.0 | 1.0 to 1.0 | 0.001 | 1.0 | 1.0 to 1.0 | 0.397 |
| All‐cause death | ||||||
| Adipsin ≥400 ng/mL | 4.2 | 1.7 to 10.6 | <0.001 | 2.8 | 0.9 to 9.0 | 0.082 |
| Men, % | 2.0 | 1.0 to 4.0 | 0.052 | … | … | … |
| Age, y | 1.0 | 1.0 to 1.1 | 0.001 | 1.0 | 1.0 to 1.1 | 0.354 |
| BNP ≥100 pg/mL | 3.6 | 2.0 to 6.7 | <0.001 | 3.8 | 1.6 to 9.2 | 0.003 |
| hsCRP ≥1 mg/L | 3.2 | 1.7 to 5.9 | <0.001 | 1.8 | 0.8 to 4.1 | 0.131 |
| BMI | 1.0 | 0.9 to 1.0 | 0.177 | … | … | … |
| Hypertension, % | 1.4 | 0.7 to 2.6 | 0.318 | … | … | … |
| DM, % | 1.5 | 0.9 to 2.7 | 0.139 | … | … | … |
| Smoke, % | 1.5 | 0.9 to 2.7 | 0.154 | … | … | … |
| Dyslipidemia, % | 1.3 | 0.7 to 2.3 | 0.412 | … | … | … |
| HbA1c, % | 0.9 | 0.7 to 1.2 | 0.555 | … | … | … |
| ACEIs, % | 1.8 | 1.1 to 2.9 | 0.032 | 1.5 | 0.7 to 3.2 | 0.273 |
| ARBs, % | 0.6 | 0.3 to 1.2 | 0.169 | … | … | … |
| CCBs, % | 0.6 | 0.4 to 1.0 | 0.053 | … | … | … |
| Statins, % | 1.1 | 0.7 to 2.0 | 0.618 | … | … | … |
| Aspirin, % | 1.0 | 0.6 to 1.7 | 0.927 | … | … | … |
| eGFR, mL/min per 1.73/m2 | 1.0 | 1.0 to 1.0 | 0.016 | 1.0 | 1.0 to 1.0 | 0.993 |
| Rehospitalization | ||||||
| Adipsin ≥400 ng/mL | 2.4 | 1.7 to 3.5 | <0.001 | 2.1 | 1.2 to 3.7 | 0.006 |
| Men, % | 0.9 | 0.8 to 1.2 | 0.508 | … | … | … |
| Age, y | 1.0 | 1.0 to 1.1 | <0.001 | 1.0 | 1.0 to 1.0 | 0.219 |
| BNP ≥100 pg/mL | 2.0 | 1.5 to 2.6 | <0.001 | 2.0 | 1.3 to 3.1 | 0.003 |
| hsCRP ≥1 mg/L | 1.5 | 1.1 to 1.9 | 0.007 | 0.9 | 0.6 to 1.4 | 0.697 |
| BMI | 1.0 | 0.9 to 1.0 | 0.010 | 1.0 | 0.9 to 1.0 | 0.246 |
| Hypertension, % | 1.1 | 0.8 to 1.6 | 0.382 | … | … | … |
| DM, % | 1.5 | 1.1 to 2.0 | 0.006 | 1.0 | 0.6 to 1.7 | 0.930 |
| Smoke, % | 0.9 | 0.7 to 1.2 | 0.616 | … | … | … |
| Dyslipidemia, % | 0.9 | 0.7 to 1.2 | 0.632 | … | … | … |
| HbA1c, % | 1.2 | 1.0 to 1.4 | 0.001 | 1.3 | 1.1 to 1.6 | 0.001 |
| ACEIs, % | 0.9 | 0.6 to 1.3 | 0.561 | … | … | … |
| ARBs, % | 1.8 | 1.3 to 2.5 | 0.001 | 1.7 | 1.2 to 2.6 | 0.008 |
| CCBs, % | 0.9 | 0.8 to 1.5 | 0.418 | … | … | … |
| Statins, % | 1.1 | 0.9 to 1.5 | 0.418 | … | … | … |
| Aspirin, % | 1.7 | 1.3 to 2.2 | <0.001 | 1.5 | 1.1 to 2.0 | 0.016 |
| eGFR, mL/min per 1.73/m2 | 1.0 | 1.0 to 1.0 | 0.003 | 1.0 | 1.0 to 1.0 | 0.550 |
| Revascularization | ||||||
| Adipsin ≥400 ng/mL | 1.8 | 1.0 to 3.4 | 0.062 | … | … | … |
| Men, % | 1.2 | 0.7 to 2.1 | 0.451 | … | … | … |
| Age, y | 1.0 | 1.0 to 1.1 | 0.011 | 1.0 | 1.0 to 1.0 | 0.818 |
| BNP ≥100 pg/mL | 1.3 | 0.8 to 2.2 | 0.285 | … | … | … |
| hsCRP ≥1 mg/L | 1.4 | 0.8 to 2.3 | 0.186 | … | … | … |
| BMI | 1.0 | 1.0 to 1.1 | 0.757 | … | … | … |
| Hypertension, % | 2.4 | 1.3 to 4.7 | 0.008 | 1.4 | 0.6 to 3.3 | 0.459 |
| DM, % | 3.5 | 2.0 to 5.9 | <0.001 | 2.0 | 0.9 to 4.4 | 0.069 |
| Smoke, % | 1.4 | 0.8 to 2.4 | 0.186 | … | … | … |
| Dyslipidemia, % | 2.0 | 1.1 to 3.5 | 0.018 | 0.8 | 0.3 to 2.4 | 0.659 |
| HbA1c, % | 1.4 | 1.2 to 1.6 | <0.001 | 1.2 | 1.0 to 1.6 | 0.093 |
| ACEIs, % | 1.5 | 0.9 to 2.4 | 0.136 | 1.2 | 0.7 to 2.1 | 0.482 |
| ARBs, % | 1.4 | 0.8 to 2.4 | 0.272 | … | … | … |
| CCBs, % | 0.6 | 0.4 to 1.0 | 0.040 | 0.9 | 0.5 to 1.5 | 0.616 |
| Statins, % | 2.4 | 1.5 to 4.0 | <0.001 | 2.6 | 1.0 to 6.7 | 0.040 |
| Aspirin, % | 2.4 | 1.7 to 3.5 | <0.001 | 1.6 | 1.0 to 2.6 | 0.047 |
| eGFR, mL/min per 1.73/m2 | 1.0 | 1.0 to 1.0 | 0.001 | 1.0 | 1.0 to 1.0 | 0.064 |
ACEIs indicates angiotensin‐converting enzyme inhibitors; ARBs, angiotensin receptor blockers; BMI, body mass index; BNP, brain natriuretic peptide; CCBs, calcium channel blockers; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HR, hazard ratio; hsCRP, high‐sensitivity C‐reactive protein.