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. 2019 Nov 22;8(23):e013130. doi: 10.1161/JAHA.119.013130

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Endothelium function assessment. A and B, Acetylcholine‐ and sodium nitroprusside (SNP)–induced hyperemias were similar in both groups (placebo, febuxostat, and febuxostat and rasburicase). C and D, Heating‐induced hyperemia after pretreatment with N‐nitro‐L‐arginine methyl ester (L‐NAME; C) was impaired in the febuxostat‐rasburicase group compared with the febuxostat group. The vasodilation response was similar between groups after pretreatment with saline (D). NS indicates not significant; PU, perfusion unit.