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. 2019 Nov 26;8(23):e013112. doi: 10.1161/JAHA.119.013112

Figure 3.

Figure 3

MicroRNA‐101 (miR‐101) overexpression or runt‐related transcription factor 1 (RUNX1) silencing led to improved cardiac function in rats with myocardial infarction (MI). The MI rats used for following measurements were injected with lentiviral vectors expressing empty vector, miR‐101 mimic, miR‐101 inhibitor, and/or small interfering RNA targeting RUNX1 (si‐RUNX1). A, The level of left ventricular end‐diastolic diameter (LVEDD) in sham‐operated and MI rats. B, The levels of left ventricular end‐systolic diameter (LVESD) in sham‐operated and MI rats. C, The level of left ventricular ejection fraction (LVEF) in sham‐operated and MI rats. D, The level of left ventricular fractional shortening (LVFS) in sham‐operated and MI rats. The data were expressed as mean±SD and analyzed using ANOVA (n=20 in each group). *P<0.05 compared with the sham‐operated rats; # P<0.05 compared with the MI rats injected with empty vector; & P<0.05 compared with the MI rats injected with both miR‐101 inhibitor and si‐RUNX1. NC indicates negative control.