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. 2019 Nov 26;8(23):e013112. doi: 10.1161/JAHA.119.013112

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Myocardial infarction (MI)–induced damage to cardiomyocytes was alleviated with the enhancement of microRNA‐101 (miR‐101) or depletion of runt‐related transcription factor 1 (RUNX1). The MI rats used for following assays were injected with lentiviral vectors expressing empty vector, miR‐101 mimic, miR‐101 inhibitor, and/or small interfering RNA targeting RUNX1 (si‐RUNX1). A, Representative images of cardiomyocytes in sham‐operated and MI rats observed by hematoxylin‐eosin staining (×400). B, The quantitative surface areas of cardiomyocytes in sham‐operated and MI rats. The data were expressed as mean±SD and analyzed using ANOVA (n=20 in each group). *P<0.05 compared with the sham‐operated rats. ^# P<0.05 compared with the MI rats injected with empty vector. ^& P<0.05 compared with the MI rats injected with both miR‐101 inhibitor and si‐RUNX1. NC indicates negative control.