Fig. 1.

Hierarchy of genomic differences and their propagation. a Genomic differences include differences in the structure (like inversions, translocations, or duplications) as well as local sequence differences like SNPs/indels. Differences in sequence can occur in syntenic regions as well as in rearranged regions. b A diploid cell containing two haplotypes, which can be distinguished by a translocation. Following meiosis and recombination, the haploid gametes can feature different copy-number variations for the translocated regions and the sequence differences in it