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. 2019 Dec 13;17(4):1559325819892702. doi: 10.1177/1559325819892702

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure. 2. — A-a, The RNA sequencing indicated that miR-196a, miR27a, and miR-206 were highly increased in EVs from BMSCs. A-b, Alizarin Red staining of osteoblasts treated with miR-196a, miR-27a, and miR-206 at 3 days. EV’s group indicated significant increase of calcium compounds after treatment of miR-196a, miR-27a, and miR-206. B, Micro-CT from 0 to 8 weeks after surgery showed that the EV delivery system (right defect) improved bone repair compared with gel group (left defect) (Reprinted with permission from⁴⁶. Copyright © 2016, Springer Nature). BMSCs indicates bone marrow-derived stem cells; CT, computed tomography; EV, extracellular vesicle.