Skip to main content
. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Hypertens Res. 2019 Apr 1;42(7):1019–1028. doi: 10.1038/s41440-019-0255-1

Table 2:

Relationship between brain arterial diameters and imaging biomarkers of cerebrovascular disease.

Right anterior SPVS score Left anterior SPVS score
Beta estimate ± SD, P-value Beta estimate ± SD, P-value
Normalized right MCA/ACA mean diameter (per SD) Model 0 0.177 ± 0.056, P=0.002 Acomm present: 0.260 ± 0.080, P=0.001
Acomm absent: 0.043 ± 0.115, P=0.59
Model 1 0.207 ± 0.056, P<0.001 Acomm present: 0.309 ± 0.080, P=0.001
Acomm absent: 0.093 ± 0.080, P=0.25
Normalized left MCA/ACA mean diameter (per SD) Model 0 Acomm present: 0.121 ± 0.075, P=0.10
Acomm absent: −0.025 ± 0.078, P=0.75		 0.041 ± 0.056, P=0.47
Model 1 Acomm present: 0.132 ± 0.074, P=0.08
Acomm absent: −0.018 ± 0.078, P=0.82		 0.056 ± 0.055, P=0.31
Right anterior WMH volume Left anterior WMH volume
Beta estimate ± SD, P-value Beta estimate ± SD, P-value
Normalized right MCA/ACA mean diameter (per SD) Model 0 −0.259 ± 0.104, P=0.014 Acomm present: −0.439 ± 0.147, P=0.003
Acomm absent: 0.056 ± 0.141, P=0.68
Model 1 −0.047 ± 0.101, P=0.64 Acomm present: −0.216 ± 0.141, P=0.125
Acomm absent: 0.259 ± 0.134, P=0.054
Normalized left MCA/ACA mean diameter (per SD) Model 0 Acomm present: −0.217 ± 0.143, P=0.13
Acomm absent: 0.019 ± 0.143, P=0.90		 −0.104 ± 0.0100, P=0.30
Model 1 Acomm present: 0.078 ± 0.135, P=0.56
Acomm absent: −0.081 ± 0.134, P=0.55		 −0.002 ± 0.094, P=0.98

Analytic note: Models adjusted for age, sex, ethnicity, diabetes, hypertension, use of antihypertensives at the time of the brain MRI, hypercholesterolemia, smoking and prior cardiac disease.

Abbreviations: SPVS, small perivascular spaces; WMH, white matter hyperintensity; SD, standard deviation; ACA, anterior cerebral artery; MCA, middle cerebral artery; Acomm, anterior communicating artery.