Table 3:
Association between pulsatile systemic hemodynamics, right sided brain arterial diameters and right anterior small perivascular spaces score
| Brachial pulse pressure (per mmHg) | Aortic pulse pressure (per mmHg) | Aortic augmentation index | ||||
|---|---|---|---|---|---|---|
| Normalized right MCA/ACA mean diameter | Beta coefficient ± standard error | P value for the interaction | Beta coefficient ± standard error | P value for the trend | Beta coefficient ± standard error | P value for the trend |
| Lower tertile | 0.0018 ± 0.0039 | <0.001 | 0.0062 ± 0.0009 | 0.014 | 0.0015 ± 0.0140 | 0.05 |
| Mid tertile | 0.0028 ± 0.0039 | 0.0124 ± 0.0087 | 0.0096 ± 0.0132 | |||
| Upper tertile | 0.0083 ± 0.0039† | 0.0163 ± 0.0086 | 0.0187 ± 0.0130 | |||
| Normalized right MCA/ACA mean diameter* Brachial pulse pressure |
Normalized right MCA/ACA mean diameter* Aortic pulse pressure |
Normalized right MCA/ACA mean diameter* aortic augmentation index |
||||
| Right common carotid strain | Beta coefficient ± standard error | P value for the trend | Beta coefficient ± standard error | P value for the trend | Beta coefficient ± standard error | P value for the trend |
| Lower tertile | 0.0025 ± 0.0017 | <0.001 | 0.0024 ± 0.0045 | 0.045 | 0.0032 ± 0.0071 | 0.06 |
| Mid tertile | 0.0030 ± 0.0015† | 0.0048 ± 0.0037 | 0.0081 ± 0.0055 | |||
| Upper tertile | 0.0045 ± 0.0017† | 0.0027 ± 0.0035 | 0.0076 ± 0.0060 | |||
| Right carotid strain* Brachial pulse pressure |
Right carotid strain* Aortic pulse pressure |
Right carotid strain* aortic augmentation index |
||||
| Normalized right MCA/ACA mean diameter | Beta coefficient ± standard error | P value for the trend | Beta coefficient ± standard error | P value for the trend | Beta coefficient ± standard error | P value for the trend |
| Lower tertile | 0.0003 ± 0.0008 | 0.001 | 0.0001 ± 0.0021 | 0.018 | − 0.0018 ± 0.0034 | 0.023 |
| Mid tertile | 0.0005 ± 0.0009 | 0.0016 ± 0.0020 | 0.0010 ± 0.0030 | |||
| Upper tertile | 0.0018 ± 0.0009† | 0.0024 ± 0.0018 | 0.0031 ± 0.0030 | |||
Analytic notes:
-The predicted variable is right anterior small perivascular spaces score
-Models adjusted for age, sex, ethnicity, diabetes, mean arterial pressure (brachial or aortic, to match the pulse pressure measure location), antihypertensive medications, hypercholesterolemia, smoking and prior cardiac disease.
-For models including carotid Doppler data, we also adjusted for time between carotid Doppler and brain MRI.
-For models including aortic measures, we also adjusted for time between echocardiogram measures, and brain MRI.
-For models including aortic augmentation index, we also adjusted for heart rate at the time of the measurements.
Abbreviations: SPVS, small perivascular spaces; SD, standard deviation; ACA, anterior cerebral artery; MCA, middle cerebral artery.
P value < 0.05