Table 4:
Association between pulsatile systemic hemodynamics, right sided brain arterial diameters and right anterior small perivascular spaces score
| Brachial pulse pressure (per mmHg) | Aortic pulse pressure (per mmHg) | Aortic augmentation index | ||||
|---|---|---|---|---|---|---|
| Normalized right MCA/ACA mean diameter | Beta coefficient ± standard error | P value for the interaction | Beta coefficient ± standard error | P value for the trend | Beta coefficient ± standard error | P value for the trend |
| Lower tertile | −0.0095 ± 0.0067 | 0.956 | 0.0069 ± 0.0132 | 0.183 | 0.0552 ± 0.0219† | 0.281 |
| Mid tertile | −0.0111 ± 0.0067 | 0.0027 ± 0.0128 | 0.0526 ± 0.0202† | |||
| Upper tertile | −0.0091 ± 0.0068 | 0.0038 ± 0.0125 | 0.0533 ± 0.0203† | |||
| Normalized right MCA/ACA mean diameter* Brachial pulse pressure |
Normalized right MCA/ACA mean diameter* Aortic pulse pressure |
Normalized right MCA/ACA mean diameter* aortic augmentation index |
||||
| Right common carotid strain | Beta coefficient ± standard error | P value for the trend | Beta coefficient ± standard error | P value for the trend | Beta coefficient ± standard error | P value for the trend |
| Lower tertile | −0.0010 ± 0.0017 | 0.403 | 0.0037 ± 0.0064 | 0.360 | 0.0038± 0.0103 | 0.156 |
| Mid tertile | − 0.0021 ± 0.0017 | −0.0092 ± 0.0053 | −0.0102 ± 0.0079 | |||
| Upper tertile | − 0.0001 ± 0.0019 | −0.0057 ± 0.0049 | −0.0086 ± 0.0086 | |||
| Right carotid strain* Brachial pulse pressure |
Right carotid strain* Aortic pulse pressure |
Right carotid strain* aortic augmentation index |
||||
| Normalized right MCA/ACA mean diameter | Beta coefficient ± standard error | P value for the trend | Beta coefficient ± standard error | P value for the trend | Beta coefficient ± standard error | P value for the trend |
| Lower tertile | −0.0009 ± 0.0015 | 0.480 | −0.0002 ± 0.0029 | 0.570 | 0.0079 ± 0.0052 | 0.493 |
| Mid tertile | −0.0015 ± 0.0015 | −0.0009 ± 0.0028 | 0.0073 ± 0.0047 | |||
| Upper tertile | − 0.0012 ± 0.0015 | −0.0011 ± 0.0026 | 0.0069 ± 0.0047 | |||
Analytic notes:
-The predicted variable is right anterior small perivascular spaces score
-Models adjusted for age, sex, ethnicity, diabetes, mean arterial pressure (brachial or aortic, to match the pulse pressure measure location), antihypertensive medications, hypercholesterolemia, smoking and prior cardiac disease.
-For models including carotid Doppler data, we also adjusted for time between carotid Doppler and brain MRI.
-For models including aortic measures, we adjusted for the time between echocardiogram measures, and brain MRI.
-For models including aortic augmentation index, we also adjusted for heart rate at the time of the measurements.
Abbreviations: SPVS, small perivascular spaces; SD, standard deviation; ACA, anterior cerebral artery; MCA, middle cerebral artery.