Figure 1.

Pruritic whole-body rash of unexplained origin. (A) Evidence of marked dermatographism and eczematous dermatitis on back (1), shoulder (2), and thigh (3). (B) Histologic findings of rash biopsied prior to OvCa diagnosis and treatment. (1) (H&E; 10×) Low-power view of right upper thigh excoriation with extensive parakeratosis. (2) (H&E; 40×) High-power view demonstrating acute and chronic inflammation surrounding a blood vessel. (C) Similar histologic findings of rash 1 yr following initial OvCa surgery and chemotherapy. (1) (H&E; 10×) Punch biopsy from the right lateral upper thigh demonstrating both deep and superficial dermatitis. (2) (H&E; 40×) Deep dermal blood vessels surrounded by inflammatory cells. The endothelial cells are rounded and consistent with a generalized reactivity phenotype.