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. 2019 Dec 12;8:F1000 Faculty Rev-2092. [Version 1] doi: 10.12688/f1000research.19909.1

Table 2. Different clinical presentations of pyoderma gangrenosum and their associated systemic diseases 3, 4, 22, 23.

Variant of pyoderma
gangrenosum
Common location Presentation Associated disease
Ulcerative (classic) Lower extremities Rapid progression
Violaceous undermined border
Very painful
Inflammatory bowel disease (IBD)
Arthritis
Myeloproliferative disease
Bullous Face Superficial bulla
Blue-gray border
Myeloproliferative disease (that is, acute
myeloid leukemia)
Pustular Legs
Upper trunk
Painful pustules
Red halo
IBD
Vegetative Trunk Superficial ulcer
No violaceous border
None
Peristomal Near stoma site Painful ulcer
Violaceous undermined border
IBD
Enteric malignancies
Post-surgical (procedural)
(after nipple piercing)
Surgery site (breast,
abdomen most common)
Rapid progression
Active and undermined border
Pain out of proportion to lesion
Fewer cases of underlying systemic disease
(compared with classic form) 23
Pyostomatitis vegetans Buccal gingiva, labial and
buccal mucosa
Multiple small white or yellow pustules
Erythema
Edema
IBD