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. 2019 Nov 27;19(1):619–629. doi: 10.3892/etm.2019.8250

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Copyright: © Quan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Longitudinal histological sections of optic nerves. (A) Representative histological section of the optic nerve in the NC-shRNA group. (B-D) Details of histological alterations in the optic nerve following ONC in the NC-shRNA group. (E-G) Details of histological alterations in the optic nerve following ONC in the lingo-1-shRNA group. (H) Representative histological section of the lingo-1-shRNA group. scale bar=50 µm. Analysis nerve cavity areas in NC-shRNA, lingo-1-shRNA and sham surgery groups at the (I) retrograde site, (J) lesion site and (K) antegrade site (n=6 mice per group). *P<0.05. Lingo-1, leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; ONC, optic nerve crush; NC-shRNA, negative control shRNA; shRNA, short hairpin RNA; NS, not significant.