Table I.
A, Latency of N1-P1 waves, µV (n=10) | ||||
---|---|---|---|---|
Timepoint | Sham ONC | NC-shRNA | Lingo-shRNA | P-value |
Pre ONC | 43.97±6.93 | 45.37±4.35 | 47.33±2.99 | 0.662 |
2 weeks | 45.23±4.07 | 65.86±6.37 | 55.98±5.04 | 0.002 |
4 weeks | 49.23±3.69 | 59.03±3.94 | 50.88±6.45 | 0.0004 |
B, Amplitude of N1 waves, ms (n=10) | ||||
Timepoint | Sham ONC | NC-shRNA | Lingo-shRNA | P-value |
Pre ONC | 32.7±2.14 | 32.37±2.53 | 33.43±2.99 | 0.554 |
2 weeks | 33.03±4.73 | 5.65±0.68 | 14.35±3.29 | 0.011 |
4 weeks | 36.27±7.81 | 5.27±3.56 | 17.06±2.89 | 0.002 |
Data are presented as the mean ± standard error. Lingo-1, leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; ONC, optic nerve crush; NC-shRNA, negative control shRNA; shRNA, short hairpin RNA.