Table 14.
Association of ABCB1 polymorphisms and drug resistance in medical history subgroups.
| Presence of medical history | Drug-resistant patients (N = 10) | Drug-responsive patients (N = 11) | ORs | 95% CI | p value | X 2 | |||
|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | ||||||
| ABCB1 C1236T genotypes | TT vs. CC+CT | 6 | 60 | 1 | 9.090 | 15.000 | 1.342-167.645 | 0.028 | 6.110 |
| TT vs. CC | 6 | 100 | 1 | 20 | 39.000 | 1.277-1190.913 | 0.036 | 7.540 | |
| ABCB1 G2677T genotypes | TT vs. GG+GT | 6 | 60 | 1 | 9.090 | 15.000 | 1.342-167.645 | 0.028 | 6.110 |
| TT vs. GT | 6 | 66.667 | 1 | 10 | 18.000 | 1.496-216.630 | 0.023 | 6.540 | |
| ABCB1 C3435T genotypes | TT vs. CC+CT | 6 | 60 | 1 | 9.090 | 15.000 | 1.342-167.645 | 0.028 | 6.110 |
| TT vs. CT | 6 | 85.714 | 1 | 12.5 | 42.000 | 2.136-825.760 | 0.014 | 8.040 | |
| ABCB1 C1236T alleles | T vs. C | 16 | 80 | 8 | 36.364 | 7.000 | 1.729-28.337 | 0.006 | 8.150 |
| ABCB1 C1236T-G2677T | TT | 5 | 50 | 0 | 0 | 23.000 | 1.070-494.601 | 0.045 | 7.220 |
Values (n and %). ORs: odds ratio; 95% CI: confidence interval; significant p value ≤ 0.05; X2: chi-square.