Table 15.
Association of ABCB1 polymorphisms and drug resistance in epileptic patients with AEDs bitherapy subgroups.
| AEDs bitherapy | Drug-resistant patients (N = 8) | Drug-responsive patients (N = 16) | ORs | 95% CI | p value | X 2 | |||
|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | ||||||
| ABCB1 G2677T genotypes | TT vs. GG+GT | 6 | 75 | 2 | 12.500 | 21.000 | 2.372-185.937 | 0.006 | 9.380 |
| TT vs. GT | 6 | 75 | 2 | 12.500 | 21.000 | 2.372-185.937 | 0.006 | 9.380 | |
| ABCB1 G2677T alleles | T vs. G | 14 | 87.500 | 18 | 56.250 | 5.444 | 1.058-28.011 | 0.043 | 4.690 |
Values (n and %). ORs: odds ratio; 95% CI: confidence interval; significant p value ≤ 0.05; X2: chi-square.