Table 2.
Brain volume.
| M (SD) in mm3 | ||||||
|---|---|---|---|---|---|---|
| Supplement (N = 33) | Placebo (N = 14) | Overall sample (N = 47) | ||||
| Pre | Post | Pre | Post | Pre | Post | |
| Gray matter | ||||||
| Global | 589258 (41075) | 583090 (43892) | 598888 (26886) | 595608 (27435) | 592127 (37387) | 586819 (39829) |
| Regions-of-interest (ROIs) | ∗ | |||||
| Prefrontal | 102435 (10156) | 101378 (10354) | 105206 (7147) | 104517 (6733) | 103260 (9372) | 102313 (9460) |
| Orbitofrontal | 23839 (2388) | 23809 (2208) | 23430 (1645) | 23590 (1719) | 23717 (2184) | 23744 (2058) |
| Anterior cingulate | 7989 (1319) | 7910 (1447) | 7887 (1055) | 7864 (1102) | 7958 (1236) | 7896 (1341) |
| Medial temporal | 27361 (2589) | 27234 (2558) | 27063 (2342) | 27234 (2658) | 27212 (2496) | 27234 (2559) |
| Hippocampus | 8681 (989) | 8407 (1050) | 9144 (743) | 8962 (886) | 8819 (939) | 8572 (1027) |
|
| ||||||
| White matter | ||||||
| Global | 437384 (74298) | 432185 (81221) | 427438 (40081) | 423846 (39899) | 434422 (65691) | 429701 (71090) |
| Regions-of-interest (ROIs) | ∗ | |||||
| Prefrontal | 84364 (8774) | 83736 (10028) | 83119 (7414) | 82317 (7317) | 83994 (8332) | 83313 (9247) |
| Orbitofrontal | 18494 (2083) | 18421 (2345) | 18141 (1484) | 18083 (1531) | 18389 (1915) | 18313 (9247) |
| Anterior cingulate | 9228 (902) | 9160 (951) | 9336 (696) | 9294 (699) | 9260 (840) | 9200 (878)∗ |
| Medial temporal | 17092 (2499) | 16955 (2736) | 16803 (2039) | 16961 (2015) | 17006 (2353) | 16957 (2521) |
|
| ||||||
| Lateral ventricle | 33250 (15696) | 35066 (16500) | 28855 (11638) | 30229 (12088) | 31941 (14622) | 33625 (15352) |
| White matter hypointensities | 7759 (14588) | 8090 (16083) | 5543 (4446) | 5625 (4690) | 7099 (12437) | 7356 (13692) |
Note: All volumes are corrected for intracranial volume (ICV) and have been rounded to the nearest mm3. ∗indicates a significant change from pre- to postintervention, p < 0.05, controlling for age and Clinical Dementia Rating (CDR) score.