Fig. 2.

Effect of TH-302 on short term radiation-induced toxicity. Immune-competent mice were treated with TH-302 and irradiated with 8 Gy in the abdominal area. 3.5 days later, toxicity in the gut and blood was assessed. Relative crypt survival and mucosal surface area in the jejunum with representative images are shown in (A) and (B). Relative plasma citrulline levels and proportion of granulocytes, monocytes and lymphocytes in whole blood are shown in (C) and (D), respectively. Data (saline n = 3, other groups n ≥ 5), mean ± SEM. *P < 0.05, **P < 0.01.