Table 1:

Genetic Variants that contribute to warfarin dose requirements and their frequencies in race/ethnic groups

			Minor Allele Frequency (%)1,2
Allele	rs number	Warfarin Dose	European	Latino	African	Asian	AI/AN3
CYP2C9*2	rs1799853	↓	10	7	2	<1	5
CYP2C9*3	rs1057910	↓	7	4	<1	3	3
CYP2C9*5	rs28371686	↓	<1	<1	2	<1	-
CYP2C9*6	rs9332131	↓	<1	<1	1	<1	-
CYP2C9*8	rs7900194	↓	<1	<1	5	<1	<1
CYP2C9*11	rs28371685	↓	<1	<1	2	<1	<1
CYP2C9 18786T	rs7089580	↑	22	12	21	1	-
CYP2C18 G>A	rs12777823	↓	15	11	25	31	-
VKORC1 −1639G>A4	rs9923231	↓	39	41	5	88	60
VKORC1 −8191A>G	rs61162043	↑	61	57	46	12	-
CYP4F2*3 (V433M)	rs2108622	↑	29	24	8	21	32
GGCX (CAA) 16,17	rs10654848	↑	<1	-	3	-	-
NQO1*2	rs1800566	↑	21	33	18	42	-
CALU T>C	rs339097	↑	<1	1	14	1	-

AA indicates African American; AI/AN, American Indian/Alaska Native; CYP, cytochrome P450; VKORC1, vitamin K epoxide reductase; GGCX, gamma-glutamyl carboxylase; NQO1, NAD(P)H dehydrogenase,quinone 1; CALU, calumenin.

¹⁾Minor allele frequencies were obtained from NCBI dbSNP 1000 Genomes using super population codes for East Asian, European, African, and Admixed American and from Perera et al. 2011 and Limdi et al. 2008.

²⁾“–” indicates that frequency is unknown or not available

³⁾Frequency estimates for American Indian/Alaska Natives were obtained from Southcentral Foundation Health Corporation Cohort (Fohner et al. 2015)

⁴⁾Frequency estimates include tag SNPs for VKORC1 −1639G>A (1173T/6484T)