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. 2019 Dec 31;38(4):472–480. doi: 10.23876/j.krcp.19.049

Figure 2.

Figure 2

Effects of tranilast on transforming growth factor-beta 1 (TGF-β1)–induced morphological changes.

The effects of tranilast on TGF-β1-induced changes in human peritoneal mesothelial cell (HPMC) morphology were observed by phase-contrast microscopy. HPMCs treated with control buffer or tranilast exhibited a cobblestone appearance (C group), while those exposed to TGF-β1 exhibited a spindle shape (T group). HPMCs exposed to TGF-β1 and tranilast reverted to a cobblestone appearance (T + TR1, T + TR10, and T + TR100 groups).

C, control; OD, optical density; T, HPMCs exposed to TGF-β1; T + TR1, HPMCs exposed to TGF-β1 and tranilast 1 μM; T + TR10, HPMCs exposed to TGF-β1 and tranilast 10 μM; T + TR100, HPMCs exposed to TGF-β1 and tranilast 100 μM; TR100, HPMCs exposed to tranilast 100 μM.