Table 1.

Inhibition data of human CA isoforms hCA I, II, IX and XII for the target sulphonamides (4a,b, 5a,b, 9a–c, and 10a–d), using (AAZ) as a standard drug.

Compound	R	R1	KI (nM)*
			hCA I	hCA II	hCA IX	hCA XII
4a	H	–	162.8	12.3	33.3	26.9
4b	Br	–	92.7	73.5	48.4	38.8
5a	H	–	37.4	33.6	60.4	10.1
5b	Br	–	63.9	44.2	27.7	32.5
9a	H	CH3	1292	643.7	32.8	49.7
9b	Br	H	2159	888.2	44.6	33.4
9c	Br	CH3	2503	571.1	10.0	16.7
10a	H	H	4625	353.9	76.6	71.8
10b	H	CH3	3921	228.5	51.1	38.9
10c	Br	H	1822	438.8	85.4	66.8
10d	Br	CH3	827.6	727.1	97.5	27.5
AAZ	–	–	250.0	12.0	25.0	5.7

^*Mean from three different assays, by a stopped flow technique (errors were in the range of ±5–10% of the reported values).