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Selectivity ratios for the inhibition of hCA IX and XII over hCA I and II for targeted compounds 4a, b, 5a, b, 9a–c and 10a–d.
| Compound | I/IX | II/IX | I/XII | II/XII |
|---|---|---|---|---|
| 4a | 4.9 | 0.4 | 6.1 | 0.5 |
| 4b | 1.9 | 1.5 | 2.4 | 1.9 |
| 5a | 0.6 | 0.6 | 3.7 | 3.3 |
| 5b | 2.3 | 1.6 | 2.0 | 1.4 |
| 9a | 39.4 | 19.6 | 26.0 | 13.0 |
| 9b | 48.4 | 19.9 | 64.6 | 26.6 |
| 9c | 250.3 | 57.1 | 149.9 | 34.2 |
| 10a | 60.4 | 4.6 | 64.4 | 4.9 |
| 10b | 76.7 | 4.5 | 100.8 | 5.9 |
| 10c | 21.3 | 5.1 | 27.3 | 6.6 |
| 10d | 8.5 | 7.5 | 30.1 | 26.4 |
| AAZ | 10.0 | 0.5 | 43.9 | 2.2 |
