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. 2019 Nov 16;23(6):371–379. doi: 10.1080/19768354.2019.1688185

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Effect of dexmedetomidine on BDNF and TrkB expression in the hippocampus. A: Evaluation of dose-dependent effects of dexmedetomidine on BDNF and TrkB expression (n = 8). (a) Control group, (b) sleep deprivation group, (c) sleep deprivation and 5 μg/kg dexmedetomidine-treated group, (d) sleep deprivation and 10 μg/kg dexmedetomidine-treated group, (e) sleep deprivation and 20 μg/kg dexmedetomidine-treated group. B: Evaluation of effect of dexmedetomidine antagonist on BDNF and TrkB expression (n = 8). (f) Control group, (g) sleep deprivation group, (h) sleep deprivation 250 μg/kg atipamezole-treated group, (i) sleep deprivation and 20 μg/kg dexmedetomidine-treated group, (j) sleep deprivation and 250 μg/kg atipamezole-treated with 20 μg/kg dexmedetomidine-treated group. * represents P < 0.05 compared to the control group. # represents P < 0.05 compared to sleep deprivation group.