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In vitro measured effective permeability (Pe) of compound 6e as well as verapamil and ranitidine using PAMPA-GIT.
A 12.5 μM concentration was used and the results are the means of three independent experiments ± standard deviation.
Verapamil (50 μM) was used as the positive control agent for the PAMPA assay.
Ranitidine (50 μM) was used as the negative control agent for the PAMPA assay.
