Table 3.

Confusion matrices for validation phases (disease present: reference standard).

Test		Result
		Reviewers +	Reviewers −	Predictive value	95% CI
Algorithm 1 (internal validation)
	Phenotype +	48	2	0.96a	0.863-0.995
	Phenotype −	1	49	0.98b	0.893-0.999
Algorithm 2 (internal validation)
	Phenotype +	20	5	0.8a	0.593-0.932
	Phenotype −	0	25	1.0b	0.863-1.000c
Combined phenotype (external validation)
	Phenotype +	53	3	0.95a	0.851-0.989
	Phenotype −	4	46	0.92b	0.807-0.978

^aPositive predictive value.

^bNegative predictive value.

^c97.5%, one-sided.