Table 7.
Main Models—Natural Log Transformation
| UCH-L1 (n = 167) | Estimate | SE | 95% CI | p Value | % Change |
|---|---|---|---|---|---|
| Intercept | 4.223 | 0.099 | 4.027, 4.418 | <0.0001 | |
| Female | −0.016 | 0.117 | −0.247, 0.214 | 0.89 | −1.6 |
| GCS <15 | 0.635 | 0.169 | 0.301, 0.968 | 0.0002 | 88.7 |
| Time | −0.043 | 0.004 | −0.051, −0.036 | <0.0001 | −4.3 |
| Positive CT | 0.710 | 0.195 | 0.326, 1.094 | 0.0003 | 103.4 |
| Positive CT*Time | 0.010 | 0.007 | −0.004, 0.024 | 0.15 | 1.0 |
| GFAP (n = 167) | Estimate | SE | 95% CI | p Value | % Change |
|---|---|---|---|---|---|
| Intercept | 3.420 | 0.105 | 3.212, 3.628 | <0.0001 | |
| Female | 0.037 | 0.146 | −0.251, 0.324 | 0.8 | 3.8 |
| GCS <15 | 0.355 | 0.209 | −0.057, 0.767 | 0.091 | 42.6 |
| Time | 0.004 | 0.004 | −0.004, 0.011 | 0.37 | 0.4 |
| Positive CT | 1.412 | 0.193 | 1.031, 1.793 | <0.0001 | 310.5 |
| Positive CT*Time | 0.036 | 0.007 | 0.022, 0.050 | <0.0001 | 3.7 |
| S100B (n = 152) | Estimate | SE | 95% CI | p Value | % Change |
|---|---|---|---|---|---|
| Intercept | 5.019 | 0.106 | 4.810, 5.227 | <0.0001 | |
| Female | 0.089 | 0.117 | −0.144, 0.321 | 0.45 | 9.3 |
| GCS <15 | 0.171 | 0.170 | −0.166, 0.507 | 0.32 | 18.6 |
| Time | −0.070 | 0.007 | −0.084, −0.057 | <0.0001 | −6.8 |
| Positive CT | 0.600 | 0.202 | 0.202, 0.998 | 0.003 | 82.2 |
| Positive CT*Time | 0.008 | 0.012 | −0.015, 0.032 | 0.475 | 0.9 |
% Change is for listed features relative to other (i.e., having a GCS <15, compared with a GCS = 15, results in a 95.0% change in serum UCH-L1 concentration) except time is for each 1-h increase. Calculated by (Estimate − 1) × 100 using unrounded estimates (rounded estimates presented in Table).
UCH-L1, ubiquitin carboxyl-terminal hydrolase-L1; SE, standard error; CI, confidence interval; GCS, Glasgow Coma Scale; CT, computed tomography; GFAP, glial fibrillary acidic protein.