FIG. 4.

Subnetwork of interacting genes with mutations potentially associated with hearing loss. We identified 10 hubs from the subnetworks extracted from protein–protein interaction database (panel A), including MYO7A, MYO6, KCTD3, NUMA1, MYH9, KCNQ1, UBC, DIAPH1, PSMC2, and RDX. The molecular functions of the subnetwork are significantly associated with known biological pathways such as Proteasome Degradation, TNF-alpha signaling pathway, and TGF-beta signaling pathway (panel B). TNF, tumor necrosis factor; TGF, transforming growth factor.