Table 3.
Top Associated Biological Pathways for the Identified Subnetwork
| Term | Overlap | p | Adjusted p | Z-score |
|---|---|---|---|---|
| Proteasome degradation | 25/62 | 5e-13 | 7e-11 | −1.90 |
| TNF-alpha signaling pathway | 28/92 | 5e-12 | 5e-10 | −1.8 |
| TGF-beta signaling pathway | 30/132 | 4e-10 | 2e-08 | −1.8 |
| Calcium regulation in the cardiac cell | 29/149 | 1e-08 | 7e-05 | −1.8 |
Pathway enrichment using Enrichr (www.amppharm.mssm.edu/Enrichr), based on genes in the subnetwork in Figure 4A; 63% of the genes within the subnetwork are annotated to the molecular functions binding (GO: 0005488) and/or catalytic activity (GO: 0003824) and are significantly enriched with deafness (p = 4.22e-15).
TNF, tumor necrosis factor; TGF, transforming growth factor.