Table 1. Selected neurodegenerative diseases, genes and regions or neurons affected.

Neurodegenerative disease	Sporadic/genetic	Genes involved	Most vulnerable regions/neuron
Alzheimer disease	~95%/5%	APP, PSEN	Entorhinal cortex / hippocampus [2]
Parkinson disease	~90%/10-15%	SNCA, PINK1, Parkin	Substantia nigra [144]
Amyotrophic lateral sclerosis	~90%/5-10%	SOD1, C9orf72, FUS and others	Motor neurons [145]
Huntington disease	100%	HTT	Medium spiny neurons [122]