Table 1 – Experimental estimates of CD8+ TRM population parameters in different murine tissues and infection settings.
Time detectable represents the maximum observed duration of TRM persistence; tissues are approximately arranged in order of increasing estimates.
| Tissue | System | Time detectable |
Population half-life* |
Self renewal |
References |
|---|---|---|---|---|---|
| Lungs | Influenza | < 210d | 5–7d | No BrdU uptake detected | (7, 69, 79) |
| Liver | Malaria | > 100d | 28–36d | (11, 70) | |
| LCMV | > 120d | (17) | |||
| FRT | HSV | > 80d | (5, 35) | ||
| LCMV | > 120d | (17) | |||
| Intestine | YPTB | > 120d | (16) | ||
| LCMV | > 120d | (17) | |||
| Brain | VACV | > 120d | <1% BrdU+ in 1 wk | (76) | |
| LCMV | > 240d | 9% Ki67+ | (12) | ||
| Skin | VACV | > 160d | (6) | ||
| LCMV | > 200d | (69) | |||
| HSV | > 540d | <5% BrdU+ in 1wk | (3, 4, 58, 83) | ||
FRT = female reproductive tract; HSV = herpes simplex virus; LCMV = Lymphocytic choriomeningitis; VACV = vaccinia virus; YPTB = Yersinia pseudotuberculosis.
*
Half-life estimates do not account for any ongoing recruitment from circulating subsets.